Welcome to NeuroTalk:

Tricia, I'd have to ask how you came to decide this?

The methylation theory from Pfeiffer Institute is not accepted by all doctors. It seems mainly in the orthomolecular psychiatry and alternative areas.

I found an interesting useful table with tests to have done to see if one could benefit from methylation manipulation:

http://www.nutritional-healing.com.a...cal%20Subtypes

Also a link for those who over-methylate:

http://www.custommedicine.com.au/unc...r-methylation/

The use of methylated folate and B12 was originally for people who have the DNA mutation MTHFR which cannot activate these vitamins in the body. I do not think that normal people without this mutation would suffer anything negative by taking the methyl versions.

B6 is not included in methylation directly because its activation is phosphorylation. But it does work with folate and B12 to make SAMe in the end. So it is only somewhat involved. SAMe then carries methyl groups where needed. But that means, the receiving end must have the enzymes ready to use a methyl group.

Now in Bipolar disorder, it is thought that overmethylation of certain parts of DNA in the genome, results in expression of Bipolar symptoms. That is a different type of methylation.
http://www.nature.com/mp/journal/v13.../4002001a.html

In fact methylation occurs in many areas of the body, and failure of this may lead to cancer.

http://en.wikipedia.org/wiki/Methylation

So you see the answer to your question is pretty complex...and almost impossible to answer.

Pfeiffer's recommendations for over-methylated patients:
Folate and B12 are indicated therefore. B3 is niacin.
By contrast under methylated people should avoid excess B6 and folate.




I would get the whole cell testing offered by Pfeiffer Institute to see exactly where you are to answer this question.

Also I have to say, that their recommendations are based on experience. Not every doctor embraces them. Trying to medicate according to over or under methylation without testing for it, seems iffy to me, because symptoms can be hard to interpret.