RLS is a major withdrawal symptom. I don't think it causes the swelling of the knees, though. My pain doc has me taking high doses of magnesium for the restless legs. It DID seem to get better when I started taking it...BUT RAMP UP. Otherwise it will cause a ruckus int he tummy, and with all the other stuff you have going on, you don't need that on top of it. Start with about 500 mg's for 3 days, and go up to 750 mgs for 2, then 1000 - if you are a "big" guy go to 1500 but the max for women is 1000. If you have an electric blanket, trying wrapping your legs (if you can tolerate it). Only other idea is walk if you can, get on the computer, read...anything to talke yuour mind off it. I have restless "body" and it's been bad the last few days cuz my patch isn't sticking well. I'm hoping it kicks in soon so I can get some sleep.