Oh its hives!! all over itchy hives! I was on it for 2+ years before I got really bad hives. Went off of it and had a flare that was terrible (first IV steroids in 14+ years of MS. So that confirmed to me that it was working. Doc and I agreed to retry it on a modified dosage and I have been hive and flare free for 3 years now (I was on Avonex for 7 years at first) Dr Weiner wrote about it in his book "Curing MS" and it does have some properties that may turn inflammatory cells into anti- inflammatory cells

goodluck