Hi Craig,

If the symptoms have not improved at all with all the medication that your wife has been taking, would it not be better to stop taking the medication? Many medication have side effects and interactions that are impossible for doctors or pharmacies to know all about. In addition, some medicine, especially combinations of medicines, may put stress on the liver, which cannot be good in the future. Especially since no noticeable benefit or change has occurred with the medicine, it might be worth it to stop taking them ... after you have discussed this with a doctor or GP, of course.

Has there been a blood test recently that indicates white blood cell count? Has a doctor looked at your wife for swollen lymph nodes? If the regular swelling is indeed due to infection, that may lead to higher white blood cell counts. Has your wife ever taken antibiotics, and has she gotten even a little relief from the swelling while on the antibiotics? That may or may not indicate the swelling as due to infection.

These are just ideas, and should be discussed with a doctor, of course.