I am by no means a doctor.

I have been diagnosed with PD for 12 years now. I noticed in the previous posts a common thread. You all seem to be taking Sinemet 25/100 and a Sinemet 25/250 name brand or generic carbodopa/levadopa. Are any of you taking SinemetCR as well or it's generic carbodopa/levodopaER?

The reason I ask is that when taking the regular Sinemet, it peaks quickly like 2 hours then drops off to to nothing before the next dose. By adding SinemetCR it keeps levodapa in your system between doses. To me it sounds like you are going off between doses. The SinemetCR acts like a cushion between doses. This is where the soreness and muscle cramping may be coming from. Another question is have you tried taking some Aleve or something similar? Aleve is an anti inflammatory.