I remember having PMDD way before it had a name. I have also been dx'd with major depression and have been on meds for 20 years for it.

In my 20s I had PMDD so bad I could be depressed three weeks out of the month! Some months it wasn't so bad, but 25-30 were some bad years. I have been waiting for menopause since age 16!!!

I never took anything specifically for the PMDD, but my underlying issues finally got attend and at least I got meds..it took a long long time for someone to take my sx seriously, and be suicidal to get the meds.

I can see how having an underlying major depression tends to confuse things. But the treatment is the same. So I guess I don't see it as an issue.