I've suffered with PMS, PMDD, and major depression all my life. I've been perimenopausal for over 10 years, living with hot flashes and night sweats that soak the sheets, and the continued PMDD issues, though I was much improved, until last year.

Last year my hormones notched it up some and are continuing to wreak havoc in my life. I also have MS which also is affected by hormone levels. During PMS my MS sx increase.

I just turned 50 and menopause is shifting into high gear now. I have a deepening of major depression which coincides somewhat with my cycle, as the moodiness takes huge leaps all month long, but is significantly worse pre period.

My GP says the years between 50-52 are some of the roughest years of for women going through The Change. I can vouch for that The thing is all I can do is continue to add more meds to my routine until this horror ride is over! My moods are so out of control, I'm crying at work when I make a mistake. Last month I couldn't even go to work 3 of the five days! Just because I could not stop crying...until I got home. No stress, no tears.

I have two years of this to look forward to?? There has got to be a better way. I've been waiting for menopause since I was 16. I've been anticipating it for more than 10, and now its going to be the worst part of my life??? I haven't been suicidal in 5 years, and now that feeling is back...I can't look at this continuing for another 2 years--minimum! I'm going to have to lock myself up somewhere. What can I do??