I have not replied to this thread but have been reading all of the responses and considering your situation. I am not on any of the dmd right now, but I am considering gylenia. I have been on betaseron, copaxone, and tysabri. I was not able to tolerate any of them - allergic reactions, antibodies, etc.

That being said, I think you really need to personally talk with your neuro about the difficulties you are having with rebif and take someone with you (maybe your best friend) who is supportive and understands/sees the problems you are having. Have you tried any of the treatments other than rebif? If not, perhaps you should consider them before making the decision to go drug free. I do think your age is one factor that should be taken into consideration. I think that deciding to go drug free when one is in their late forties/fifties and after trying a number of other treatments may make more sense than making this decision at this stage in your life.

That being said, I agree with Kelly that ultimately this is your decision and your body.