Quote:
Originally Posted by mrsD
Tramadol does not contain serotonin per se.
But it does act on serotonin receptors. This may be a function of the action it has on mu receptors (pain area) and other receptors like the kappa one.
Some opiates also do this. Oxycodone has quite a serotonin connection in some people.
Some neurotransmitter actions are cascades...initiated by one system and then a second one becomes active. Histamine in the brain is like this, initiating other systems.
The bottom line is that many drugs overlap onto other systems and have actions that complicate things for people.
Some of these are discovered during trials, but many take years and years to come forward, during post marketing.
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Thank you for this thorough explanation. Sadly, one of my doctors Rx'd me flexeril while on the extended release formula of tramadol and within a day things were getting weird for me. After a couple of days it dawned on me to check the contents of it and thats when I realized what was happening. Even more sad was the fact that I brought it to the doctors attention. Now I just tell all of them that I won't touch anything with serotonin in it. That was a very scarry situation for me.