Originally Posted by mrsD

Alot depends on the dose of Tramadol used. Tramadol has some serotonergic potential and can be additive with SSRIs. Cymbalta is a mixed SSRI + SSNI product.

Here is a drug checker:

http://www.drugs.com/drug_interactions.html

Another good resource is www.rxlist.com for details on most common drugs used today. Use Ultram for the search on tramadol there.