I have taken Betaseron since 2002. The injection site reactions have not gotten any better over time and I have bruises where I did shots 6 months ago!
I can not do my arms at all. It hurts like he**!
Sometimes I do a "bad" shot and the site gets all hard and sore.
Do you use an injector? I find that to be a bit more consistant. However; the drug has worked pretty well for me and I don't feel "sick" after taking it.

I would like to try something else just to help my skin out!
I find that massaging the injection site using an ice pack helps reduce the severity of the reaction.
You need to get in contact with a Beta Nurse and go over some of your concerns. There number is 1-800-788-1467 and are available 24/7. They hear it all from the patients they serve and can have some really good insight. They can get you an injector also.