I switched from Doxepin to Savella back in March. I honestly haven't noticed a difference so I can't really say how much it has been helping or not. I take 50mg 2x daily. I haven't noticed any BAD side effects from it though either. Though I just started taking Cymbalta too and have been getting violently ill from that. Could just be I'm not reacting well to the Cymbalta specifically (which is what I think), but I suppose it's possible that it's interacting with the savella since they are in the same family of medications and the double up might be causing problems. Sorry I can't be more help with this, but I do take the savella and even though it didn't make a noticeable helpful difference, it didn't cause any harm either.