Did not work for my daughter (7 treatments) but I know many it has worked for. I was told it would not work with previous ketamine exposure but someone I talked to last night had used ketamine and a scs and is doing much better with Calmare then anything else. I also wonder if the doctor I used in Va did it correctly. He was new to it. Many doctors will let you try one time for free. I did learn from the salesman that if it is going to work, you should know right away...even if it doesn't last it will give you relief when applied.