http://www.labmate-online.com/news/n...eatment/15643/" The part of the brain most affected by dopamine depletion as a result of Parkinson's disease is the striatum which is divided into several structures.

In Parkinson's disease, the dorsal striatum is more severely affected while the ventral striatum remains largely unaffected in the early stages.

"We observed that while dopamine replacement therapy enhances the functions of the dorsal striatum, it is at the expense of the ventral striatum which suffers a dopamine overdose, impairing its function", Dr Monchi explained."