i take nortriptyline and have been waking up on. I take medication right away and have a little off and dystonia, sometimes none. i take 50 mgs of it at bedtime. Before was taking it in 10mg tabs throughout the day. Neuro suggested a 50 mg tab all at once. It's bought me some time and I can still increase the nortriptyline as high as 150 mg. That and brand name sinemet [$70 copay] which i find to be much smoother have really helped me with the dreadful D.