I was neutered at a young age, so I have been on HRT for eons. It helps MS for some people. That trial is one of many that says Estrogen (Estriol) may help with MS. So I am like Wiz.
If you still have your Uterus you need progesterone too. That is the one that gives you problems, it is risky, and can cause spotting, etc.
If you can make it without drugs, do that. Some have short menopause times and easy ones too. Good luck. Women are so lucky. We get all the fun stuff. Ha ha ha