I've been on LDN since January.

I definitely have improved state of well-being and have been flare-free, but then again I've been on Tysabri since August so that may be why.

BUT I do want to point out that LDN can make spasticity worse. My legs have some minor permanent damage from the last flare, and it got worse when I was on a higher dose of LDN (4.5) and got better almost immediately (within 2 days) when I dropped down to 2 mg.

JD