Subject: Alzheimer-type neuropathology in a 28-year old patient with iatrogenic CJD after dural grafting
Date: March 9, 2007 at 9:15 am PST
HUMAN-04
Alzheimer-type neuropathology in a 28-year old patient with iatrogenic
Creutzfeldt-Jakob disease after dural grafting
M Preusser1, T Stroebel1, E Gelpi1, 2, M Eiler3, G Broessner4, E Schmutzhard4, H Budka1, 2
1 Institute of Neurology, Medical University Vienna, Austria; 2 Austrian Reference Centre for Human Prion Diseases
(OERPE), General Hospital Vienna, Austria; 3 Department of Neurology, LKH Rankweil, Austria; 4 Department of
Neurology, Medical University Innsbruck, Austria
We report the autopsy case of a 28-year old male patient who had received a cadaverous dura
mater graft after a traumatic open skull fracture with tearing of dura at the age of 5 years. A
clinical suspicion of Creutzfeldt-Jakob disease (CJD) was confirmed by a brain biopsy 5 months
prior to death and by autopsy, thus warranting the diagnosis of iatrogenic CJD (iCJD) according
to WHO criteria. Immunohistochemistry showed widespread cortical depositions of diseaseassociated
prion protein (PrPsc) in a synaptic pattern and western blot analysis identified PrPsc of
type 2A according to Parchi et al. Surprisingly, we found Alzheimer-type senile plaques and
cerebral amyloid angiopathy in widespread areas of the brain. Plaque-type and vascular amyloid
was immunohistochemically identified as deposits of beta-A4 peptide. CERAD criteria for
diagnosis of definite Alzheimer´s disease (AD) were met in the absence of neurofibrillar tangles
or alpha-synuclein immunoreactive inclusions. There was no family history of AD, CJD, or any
other neurological disease, and genetic analysis showed no disease-specific mutations of the
prion protein, presenilin 1 and 2, or amyloid precursor protein genes. This case represents 1. the
iCJD case with the longest incubation time after dural grafting reported so far, 2. the youngest
documented patient with concomitant CJD and Alzheimer-type neuropathology to date, 3. the
first description of Alzheimer type-changes in iCJD, and 4. the second case of iCJD in Austria.
Despite the young patient age, the Alzheimer-type changes may be an incidental finding, possibly
related to the childhood trauma.
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