Carnitine biosynthesis requires several steps.
http://en.wikipedia.org/wiki/Carnitine
If any of these are damaged, the enzymes helping with its conversion fail, then the carnitine is not made.
We know of one drug which interferes with this, and it is called Depakote. Others are the antivirals used for treating HIV positive people. Nutrient depletion is still an infant science...so many things may still be out there and unevaluated yet.
Regarding the curcumin:
Quote:
Adverse Effects
In the United States, turmeric is generally recognized as safe (GRAS) by the FDA as a food additive by the FDA (82). Serious adverse effects have not been reported in humans taking high doses of curcumin. A dose escalation trial in 24 adults found that single oral dosages up to 12 g were safe, and adverse effects were not dose-related (5). In a phase I trial in Taiwan, curcumin supplementation up to 8 g/day for three months was reported to be well-tolerated in patients with precancerous conditions or noninvasive cancer (8). In another clinical trial in the UK, curcumin supplementation ranging from 0.45-3.6 g/day for four months was generally well-tolerated by people with advanced colorectal cancer, although two participants experienced diarrhea and another reported nausea (9). Increases in serum alkaline phosphatase and lactate dehydrogenase were also observed in several participants, but it was not clear whether these increases were related to curcumin supplementation or cancer progression (1). Curcumin supplementation of 20-40 mg has been reported to increase gallbladder contractions in healthy people (83, 84). Although increasing gallbladder contractions could decrease the risk of gallstone formation by promoting gallbladder emptying, it could potentially increase the risk of symptoms in people who already have gallstones.
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from
http://lpi.oregonstate.edu/infocente...cals/curcumin/
There are other antioxidants out there --but curcumin is the most studied for endothelial protection. It is equivalent to statins for this use. Which brings up the subject... Statin drugs are known contributors of PN and other serious things. If you are taking one please discuss this with your doctor.
Notice from the Wiki link that Vit C is necessary to making internal carnitine. Also it is thought that with age this system may fail to provide it reliably and with chemo damaging systems and the cancer taking the nutrients from normal cells, it may be low for those reasons.
Other antioxidants include Vit C, vit E, astaxanthin, grapeseed extract, citrus bioflavinoids, and many foods like blueberries and strawberries among other highly colorful fruits and veggies.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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