You have no idea how big that elephant is under that rug. Years and years of chronic stress and then a sudden acute stress. The first prepares the ground and the second ignites the blast.

My CV-
Born 1953. Alcoholic father. Neurotic mother.
Some depression in late teens but had a sort of epiphany where I chose to live.

Beginning about 1975 and in approximate order-
Mother attempted suicide.
I married.
Father succeeded at suicide.
Wife and I remodeled and sold house.
Remodeled mobile home and moved in.
Burned due to lightening.
Built house ourselves.
Burned by arsonist.
Wife having health problems, in wheelchair for months.
Became livein caregivers for first of four grandparents over an eight year period. No privacy and incredibly hard.
Oh yeah, running a small business all along.
Exposure to chlordane.
Last grandparent died.
Had house built. Still in it.
Still running small business. One vacation in 20 years.
Wife having more health problems.
1992 First tremor. Brother died.
1999 major case of flu
2000 diagnosis.
2000 to 2009 Relatively stable but slow decline
2009 Business failure began
2010 First endocrine problems showed at peak of stress (panic attacks, periodic paralysis, hot flashes)
2010 to 2011 Marked decline