I have been on Lunesta 2mg, now 3mg. probably three years now. The doctor put me on it when I was on Lyrica, so I could sleep during the night. I haven't had any trouble with it. I have so many aches and pains once I lay down, it helps with that and just helps me drift to sleep easier. Once in a great while, like every two weeks, I have a lot of pain in my legs and cramps, hips hurt, it won't work right away, but most the time it does. I wake up at usual time, have overslept a couple of times, but I don't use an alarm.
It is a tier three co-pay for me, so I applied online for a Lunesta card, it is paying my $50 co-pay, so I pay $0, which has been nice. I also do that for my Dexilant for reflux.
Good Luck MM, Have never taken Benedryl with it, but take Clonazepam twice a day, hasn't changed how Lunesta works for me.