Abby, Here's my old post on that.

http://neurotalk.psychcentral.com/thread80534.html

Here are a few articles.

http://www.ncbi.nlm.nih.gov/pubmed/2003276

http://jpet.aspetjournals.org/content/273/2/637.short

http://www.ncbi.nlm.nih.gov/pubmed/89675

Sorry if I'm repeating myself but I didn't read through the original post. Caffeine has been shown to be a cholinesterase inhibitor, like Mestinon. They inhibit acetylcholinesterase, the enzyme whose job it is to "clean up" after acetylcholine is done of it's job making muscles strong. If it didn't, muscles may become too weak from too much acetylcholine (in people with or without MG).

Coffee and Mestinon aren't, obviously, the same animal. Until coffee is thorough evaluated, it's hard to say what other properties are at work. Caffeine does increase dopamine, which is why caffeine makes people feel more alert. Coffee has large amounts of potassium too, which you have been low on in the past.

Calcium may be more at play here than ACh. Perhaps you have a CMS, who knows. "Channelopathies" involve electrolytes like calcium. I can't remember, did they try IVIG on you? Sometimes with "seronegs," they do IVIG or plasmapheresis to look for improvement. If there is, they know it's autoimmune MG.

Well, those are my thoughts. I know you want more proof but don't beat yourself up trying to find it.

Annie

Oh, and about that not noticing thing. Are you SURE you didn't? Were there any physical activities you couldn't do as a child? Any that you did less of than others? Did you nap in the afternoons (past the time you "took" naps)? I had so many clues growing up that I simply ignored. I thought I just had to try harder.