Originally Posted by mrsD

The most likely antibiotic for a bone infection is clindamycin (Cleocin). This is not implicated in PN.

But you have every right to ask what you will be given.

Perhaps they will culture the biopsy and find the antibiotic to fit what shows up?

There are so many IV choices... and the bottom line with this serious thing...is that the risk in this case is high, and you will have to take what they give you. But you have every right to ask and discuss any fluoroquinolone like Cipro or Levaquin or Zyvox or Flagyl, and see if there are alternatives. There may be not. All three of these drugs are implicated in PN generation.

If your vertebra is consumed by infection...you will be in a far worse place than having PN. So the doctors will have to weigh benefit vs risk, in this case.