Ron,

You write,

"A reduction in permeability to that below the threshold of dopamine leakage would constitute a cure."

A reduction in permeability would be nice, but in the meantime can we not find a way to make permeability work in our favour?

If I understand your theory correctly, PwP leak dopamine, with those most severely affected leaking the most.

Do you propose the leakage is in both directions?

If so, and if the cardiovascular impact of dopamine can be dealt with safely, the theory would suggest that taking dopamine orally would get dopamine into the brain, leading to a reduction of symptoms, especially so for those most severely affected. Eventually the in-flows to the brain would equal the out-flows, and concentrations would stabilize. Unfortunately, this could be before normal levels are reached.

Or, even more simply, the theory suggests that eating a banana should give some relief.

John