I've posted these two articles before, where it basically says that Mestinon might help patients who have ischemia, a lowered or inadequate blood supply in an area of the body.

http://www.ncbi.nlm.nih.gov/pubmed/17397949

http://www.ncbi.nlm.nih.gov/pubmed/15367503

But silly me didn't take that one step further to figure out why. I was doing some research on blood thinners, platelets, etc. and came upon this info.

http://www.ncbi.nlm.nih.gov/pubmed/19694313

http://www.mjpath.org.my/2009.1/07pyridostigmine.pdf

So, what Mestinon can do is act as a blood thinner. And, if you stop taking it for any extended period of time, it is possible that your blood can become thicker due to more platelet aggregation (clotting). Whether that makes you more prone to clots is hard to say. But like any other drug, if you stop taking it, symptoms can become more pronounced afterwards. Kind of like the new warnings about stopping Plavix and being more prone to a stroke or heart attack.

Those patients with CMS's with too much acetylcholine who take Quinidine can have the opposite effect. Taking it may cause more clotting.

You'd think that would be an important little "factoid" to put on the prescribing information of the drug.

I take baby aspirin daily and the combo of those two could cause bleeding. Very interesting since I had a little biopsy in 2004 that lead to hemorrhaging. They couldn't find any reason for it. Who knows if that was the cause or not.

So if you have any clotting disorder like APS (antiphospholipid antibody syndrome) or lupus clotting issues or any peripheral artery disease or any other cardiovascular concern, please bring this up to the appropriate doctor!

http://www.valeant.com/fileRepositor...g_PI_May01.pdf

Nope, can't find any reference to it. Keep up the good work, Valeant.

One more reason to be well-informed and to keep your doctors up-to-date on information.

Annie