I've taken amantadine for almost the full 10 years I have been diagnosed with PD, along with sinemet and antidepressants (currently welbutrin and cymbalta). A couple of months after starting out with 200 mg amantadine, my feet and ankles swelled rather badly. Backing off to 100 mg resulted in the swelling going away. I still have some "purple blotchies", especially in cold weather. No other side effects from amantadine that I am aware of.