Rach, I'm still not sure that thinning the blood would be what would raise blood pressure upon standing. I would think the opposite would happen, since people with ischemia often have higher blood pressure. Obviously, Mestinon has more effects on the body that what has been elucidated in the prescribing information or on websites like MGFA.

If someone goes off of Mestinon and does have any clotting/platelet issues, it could be very dangerous for them. It might effect the Prothrombin Time or INR.

http://www.medpagetoday.com/Cardiolo...ertension/2676

They noted that the greatest increase was in diastolic BP, not systolic (upper number). I'll have to research this some more.