At this point, I'm not sure my stomach issues have had anything to do with Topamax since I first started it. I've gone up and down on the dose so many times now and it really doesn't seem to make a difference, I've been on 300mg steadily now for four months. I think its more likely just coincidence when I had all the problems the first time. I think it's more likely that my RSD has been spreading internally over the past six months due to a number of other symptoms I've had. The only part there that doesn't make sense is that all of my Ketamine treatments should have stopped it but what do I know? I guess I'll have to suck it up and get the colonoscopy done to be sure. I'm just scared to death of them perforating or tearing anything and causing RSD to spread then.