I was prescribed Clonidine during the 1st year that I got RSD. It is supposed to calm down your nervous system. I had to discontinue use for a few reasons. First, my blood pressure is normally around 90/60.... since Clonidine is a med designed to lower your blood pressure.....it lowered my bp way too low. Also, I was using the patches & I was allergic to the adhesive. It really irritated my skin & itched very bad. So, the patch was always on my mid back. I would wake up in the night & had ripped it off while I was sleeping. It would be stuck anywhere from in my hair, on the bed sheets, to on my boyfriends arm hahahaha!!!! Anyways, it didnt help for me & I couldnt take it, but maybe it will help others. I am about to have to take it very temporarily. I am switching pain meds & they are giving it to me for the detox/withdrawal process. Hope this helps & it works for you!!