I had severe nerve damage of my legs secondary to compartment syndrome. Neurotin was prescribed but was ineffective. I subsequently began taking Lyrica with great results. Though quite expensive, the effectiveness of Lyrica was undeniable. I eventually ramped up to 300mg, twice daily. The relief was essential during recovery. The side effects have been mostly minimal, with some pleasant effects, early on. But, when attempting to wean off, the side effects were horrible. Anxiety, difficulty breathing, insomnia, depression, suicidal thoughts etc. At such a high dose, my brain chemistry was seriously altered. I returned to my original dose to stop the withdrawal symptoms. Miserable. I will consult my physician again for recommendations. I refuse to go on benzodiazepines because of the awful withdrawal of those drugs. I believe a very slow ramp down in dosage and a to be expected period of discomfort.