At the point of 50 lbs. weight loss, my neuro gave that as one reason for my reduced need for dopamine. The other reason was greatly increased exercise, which helps us use our meds more efficiently. I have gone from five or six 25/100 brand name Sinemet per day to four or five, or even three if I'm just lying around. I also take 15 mg/day of Requip, 40 mg/day of KW6002 (experimental), Comtan with each dose of Sinemet, and 60 mg/day of Cymbalta.

Jaye