Thanks Paula.

I am glad they know more about it! So alpha-syn seems to form a tetramer (four single units forming some kind of a structure which makes it easier to visualize it as a chaperone protein and/or whatever else it does.

This new finding does not take away any of the information we already know about alpha-syn. Mutations in alpha-syn could still prevent tetramer formation, monomers could be aggregating to form oliogomers...... and eventually leading to neuro inflammation.

Alpha- Syn is clearly an important protein in the neuron and when it fails to do its job (whatever it may be!), there is a big problem called PD.

Thanks for posting this Paula.

Girija