New Treatment Approach For Alzheimer's Disease



http://www.medicalnewstoday.com/releases/232847.php

Universitätsmedizin Berlin and Universitätsklinik Freiburg succeeded in documenting how the immune system can counteract the advancement of Alzheimer's disease... their neuroscience paper they showed that certain scavenger cells in the immune system, so-called macrophages, play a key role in this context. Furthermore, they were able to demonstrate how special cell-signaling proteins, so-called chemokines, mediate the defense process...

...For ten years now the scientists have been investigating the exact role of macrophages in neurodegenerative diseases. "Macrophages can reduce harmful deposits in the brain that are the cause of Alzheimer's disease," Prof. Priller explains.

In an animal model the research team was now able to show which certain subset of macrophages is responsible for reduction of the deposits. Contrary to earlier academic opinion, this defense reaction cannot be handled by the immune cells of the brain, the microglia, because they themselves are damaged by the pathological process. Instead, specialized bone marrow-derived macrophages are activated and directed into the brain to remove the toxic deposits. The carrier cells receive the command to specialize and infiltrate the brain in the form of certain cell-signaling proteins. The researchers managed to identify a specific chemokine for the first time....

"In future we hope to be able to systematically introduce specialized scavenger cells to the brain and thus speed up the reduction of Alzheimer's disease deposits," says..."