Some other opiates have a serotonin stimulating component too. Oxycodone is one. The itching some people get from synthetic opiates is thought to be serotonin triggered.
The mu receptor does cross react with stimulating serotonin receptors. Some drugs like tramadol have this mixed action more than other opiates.
If you google oxycodone serotonin you can read about it in more detail.
Tramadol mixed with Flexeril increases seizure risk as well as both have mixed serotonin weak agonism.
Tramadol in high doses can trigger seizures in some patients.
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Weezie looking at petunias 8.25.2017
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