Tramadol is serotonergic as well.

Ultimately, I think a lot of us have tried a significant number of these medications, and really, none of them work totally. It's a personal journey to find what works 'somewhat' and doesn't cause you a lot of side effects. Some are luckier than others. The best I get to is feeling is, like I was run over by a truck....and the worst, wishing that truck had done me in.

Neuropathy is vast in scope and on a continuum. It is a component of hundreds of diseases, and also a disease on it's own. The only issue I see, is the potential for more drugs to interact....versus using one or two that don't. My personal opinion is that serotonin is a bit over-rated. If some is good, more is not always better. It's pretty much like that with all drugs.

It's not a judgment issue, it's no value attached. If serotonin works, great, if opiates work, fine. Like I said, I would eat raw yak liver, if it worked. I would hold my nose tho.