I had 5 rounds of PLEX last year prior to thymectomy and it lasted about 6 weeks before I had to start increasing my mestinon dose. Within a month I started IVIG. I wonder how long PLEX would have worked if I hadn't had the huge stress of major surgery. I just had another round last week and felt better the very next day, so much better and faster than IVIG. Since I am seronegative it really is a confirmation of my diagnosis for me.

Tyson, please explain "it could have been life threatening on immunosuppressants". I am not currently on immunosuppressants but know of others who are and who receive PLEX treatments.