Despite the widespread use of SdG in Amazonia as an analgesic,
antidiarrheal, and wound-healing agent few in the Western world
are aware of its existence and little is known about how it achieves
these therapeutic beneŽts. We postulated that these beneŽts may
result from a suppression of sensory afferent nerve activation and
the present results support this conclusion. This hypothesis was
generated from experience and the knowledge that sensory afferent
nerves serve as broad-based sentinels in the skin, gut, and lung, and
that the rapidity by which SdG relieved pain and itching was
consistent with a neurogenic mechanism. In addition, the
serendipitous personal observation by an author that SdG relieved
the symptoms of cutaneous capsaicin (sensations associated with an
overly spicy meal) focused our attention to sensory afferent nerve
mechanisms.
SdG appears to suppress the activation of sensory afferent nerves
at a prejunctional level, in addition to inhibiting the tissue responses
to CGRP, a primary neurotransmitter of sensory afferent nerves.
Supporting the present Žndings we recently noted that SdG was
able to attenuate the epithelial secretory response to capsaicin but
not the neurokinin-1 antagonist

[...]

It is interesting to note that SdG was an effective analgesic and
anti-in¯ammatory agent when applied topically, even when the
hyperalgesic stimuli were applied by intradermal injection. This
suggests that active components have sufŽcient lipophilicity to
readily cross the skin. From the observations from the pest control
workers who noted symptomatic relief in less than 2 min, this
transcutaneous absorption appears to be rapid.

[...]

The dual prejunctional and postjunctional effects of SdG on
sensory afferent mechanisms (nerve activation and CGRP receptor)
inhibition) are unique and are consistent with both the rapidity and
breadth of SdG's beneŽts

[...]

The goal of this approach is to deplete the sensory afferent nerve
terminals of neurotransmitters in order to limit their contribution to
both the pain signal and the local tissue responses. This result is
achieved, however, by the acute activation of the precise
mechanisms that one is trying to block, and is in essence a clumsy
approach to therapy. A more speciŽc approach, however, has not
been available. SdG offers a different approach to managing
disorders characterized by excessive or sustained activation of
sensory afferent nerves (neurogenic in¯ammation) ą rapid suppression
of nerve activation.

http://reparagen.net/PDF%2015.pdf

“Not only does Sangre de Grado prevent pain sensation, it also blocks the tissue response to a chemical released by nerves that promotes inflammation. There is currently no other substance that we know of that shares these same activities”

http://naturalscience.com/ns/news/news27.html

If it's not fake, we need that now !