imad, i was guilty of skimming it the first time too altho i knew you were correct about it being barely past the 60s today. i read it this morning word for word and it couldn't be more clear.
they concluded and asked for more study on two systems that are the basis of why i take the drugs i take.
dopamine/acetylcholine system
serotonin/ histamine system
that's why i take nortriptyline and amantadine which have anitcholinergic properties and boost norepinephrine for serotonin [nortriptyline does the latter]. i take a ton of sinemet tho, but up to about 5:00 pm then i can back off from the build up and often get by with mostly nortriptyline and 3 xanax - 1 at dinner time and 2 at bedtime. all low dose and take only 25/100 sinemet. it's a lot of med, but then i've had it for more than 20 years. what is saving me now?
the dreaded words i used to despise; vigorous exercise. now i do them with 5lb weights around my ankles. all aquatic, 5 hours per week. i have a recumbent bicycle which i am guilty of not using but it has not come to the point where i am hanging laundry on it to dry. i look at it tho.
adding: i loved the last statement about subtypes and mental illness.
"Depending on the intensity of the disturbance affecting predominantly one or the other of these two systems, symptomatology in the parkinsonian patients will vary in the relative proportion of tremor and rigidity present. We feel that this hypothesis, still incomplete, will serve
as a useful theorem in the study of this elusive entity called Parkinson's disease and may even be brought to bear on the problem of mental illness."