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Old 09-13-2011, 06:58 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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There is one website I have found:

http://www.chiro.org/nutrition/ABSTR...orticosteroids

I am not sure how complete that one is either.

The reference I use only gives two things for Depakote.
The carnitine and folate. (however it was written in 2001)

The Side Effects Bible...a newer book lists:
B12
VitD
Melatonin
Sodium
Selenium

in addition to carnitine and folate.

I don't know where that list comes from...however. Some anticonvulsants are thrown together based on the other drugs in that family.
The reference I use only is based on Medline papers published.

So I did a PubMed search on valproic acid B12 depletion and got no hits.

However, Depakote does block methylation of epigenetic DNA and that is a theory on how it helps bipolar.

Both B12 and folic acid have to be methylated to be useful in the body, so maybe this methylation issue is why those show up on the second list.

Vit D loss is listed for almost all anticonvulsants, because some have shown this interaction, so it is extrapolated to all.

The zinc may be the same. Zinc has always be recommended for hair loss, and Depakote does cause this in women. So shrinks have recommended this intervention. But I think in women the Depakote is really changing hormonal status and that is known to cause hair loss in women. Depakote is very hard on the sex hormones for both sexes! That IS documented.
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mymorgy (09-13-2011)