I just got back from a cross country trip and flight. I made sure to have my meds, i wore an eye mask to block the light, made sure my neck was secure with a sleep pillow, had and ipod to listen to if other noises annoyed me, and premedicated with pain medicine. I did pretty good. I also went to Disney World with a 2 year old, so i think my pure exhaustion afterwards has more to do with that than the flight it self.