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Originally Posted by JrnFla
I've been on them so long they have little effect any more but I have little choice.
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Is anyone monitoring your adrenal hormones? Opioids can suppress adrenal hormones, and supplementation/replacement may improve opioid efficacy.
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Serum pregnenolone may drop to subnormal levels when patients are maintained on opioids. In these cases, patients complain that their medication is “no longer working.” Opioids may suppress pregnenolone production and require replacement as is the case with testosterone.
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http://www.practicalpainmanagement.c...in-update-2010
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