Prednisone has also caused me to have type 2 diabetes weight gain/puffiness, moon face i have taken Prednisone for 3 years straight and then weaned off . 2 years no Prednisone but the type 2 diabetes never went away now i am back on the Prednisone and have been on it going on 2 1/2 years and the diabetes is now getting out of control also starting to have problems with my kidneys and have gained alot of weight and cant seem to take it off i wish i had never started the Prednisone but you are right it does work without it i feel i would have been in and out of the hospital it has helped me to get stronger but yet if causes so many problems