I've read in several places that R-lipoic works better in conjunction with both Acetyl L-Carnitine and Pantothenic Acid (vitamin B-5) supplementation. I started on R-lipoic alone, and it stopped most of the burning within days. A few months later I added ALC and there was further improvement. A few months after that, after reading about B-5, I added that as well, and that has helped even further with most of the needle jabs, cramping, and some of the hypersensitivity to pain.

Doc