I'm looking around for verification....
So far I found this... Carnitine useful in both hyper and hypo states:
http://www.ncbi.nlm.nih.gov/pubmed/15803480
Quote:
Muscle Nerve. 2005 Sep;32(3):357-9.
Muscle carnitine in hypo- and hyperthyroidism.
Sinclair C, Gilchrist JM, Hennessey JV, Kandula M.
Source
Department of Neurology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA.
Abstract
Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction. Skeletal muscle samples were obtained for carnitine analysis from control subjects, and from hyperthyroid and hypothyroid patients before and after treatment. There was a significant reduction in carnitine, especially the esterified portion, in hyperthyroid individuals, with a return to normal as euthyroid status was regained. In hypothyroid patients, there was a trend for carnitine to be lower than normal and for improvement once euthyroid status was attained. Our data indicate that muscle carnitine levels are affected by both hypo- and hyperthyroidism. A decrease in muscle carnitine in both conditions may contribute to thyroid myopathy.
PMID:
15803480
[PubMed - indexed for MEDLINE]
|
And this giving dose suggestions:
Quote:
Ann N Y Acad Sci. 2004 Nov;1033:158-67.
Effects of carnitine on thyroid hormone action.
Benvenga S, Amato A, Calvani M, Trimarchi F.
Source
Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e Farmacologia, University of Messina School of Medicine, 98125 Messina, Italy. s.benvenga@me.nettuno.it
Abstract
By experiments on cells (neurons, hepatocytes, and fibroblasts) that are targets for thyroid hormones and a randomized clinical trial on iatrogenic hyperthyroidism, we validated the concept that L-carnitine is a peripheral antagonist of thyroid hormone action. In particular, L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell nuclei. This is relevant because thyroid hormone action is mainly mediated by specific nuclear receptors. In the randomized trial, we showed that 2 and 4 grams per day of oral L-carnitine are capable of reversing hyperthyroid symptoms (and biochemical changes in the hyperthyroid direction) as well as preventing (or minimizing) the appearance of hyperthyroid symptoms (or biochemical changes in the hyperthyroid direction). It is noteworthy that some biochemical parameters (thyrotropin and urine hydroxyproline) were refractory to the L-carnitine inhibition of thyroid hormone action, while osteocalcin changed in the hyperthyroid direction, but with a beneficial end result on bone. A very recent clinical observation proved the usefulness of L-carnitine in the most serious form of hyperthyroidism: thyroid storm. Since hyperthyroidism impoverishes the tissue deposits of carnitine, there is a rationale for using L-carnitine at least in certain clinical settings.
PMID:
15591013
[PubMed - indexed for MEDLINE]
|
from:
http://www.ncbi.nlm.nih.gov/pubmed/15591013
When taking carnitine, it is best to space out the doses, because there is a limit to GI absorption for each dose.
I saw one paper where the carnitine was given IV...for a thyroid storm (hyper).
http://www.ncbi.nlm.nih.gov/pubmed/21739342
This paper has no details or abstract tho.
This article goes into detail which might be helpful for you:
http://www.lef.org/magazine/mag2007/...thyroid_01.htm
What dose were you on, when this happened, if you don't mind sharing that?
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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