I have had trouble with constipation most of my life. My doctor told me to use a vegetable laxative daily, when I was diagnosed with peripheral neuropathy. The neuropathy pain has been unbearable at times this summer - we've had the hottest weather that I remember and it seems as though my feet particularly were swollen. I decided to go cold turkey and quit all caffeine. My feet and hands are still hurting, but the swelling is gone and the bathroom issue has resolved itself totally. One less pill to take.