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Old 09-27-2011, 05:00 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

It is better to take all at once... on empty stomach.

If you have intact intrinsic factor this is less of an issue.

But those who show up here with lows, have some problem or they would not be low and have the neuro symptoms.

When intrinsic factor is not working (for whatever reason), the only way B12 is absorbed is by passive osmosis thru the lining of the GI tract. The higher the concentration present, the more that will get thru. 5mg will result in more being absorbed, which is still a very small amount. 1mg also is absorbed, but 5 times less than the larger dose.

Some things have receptors controlling absorption, or a biochemical barrier. Zinc, magnesium, calcium, carnitine, Neurontin, are examples of limited absorption, needing perhaps divided doses.
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MelodyL (09-27-2011)