Today I am searching B12 and immunity (mostly for my cat), but I found these papers which are useful for us, here:
http://www.ncbi.nlm.nih.gov/pmc/arti...able/T1/#TF1-4
This one above is a chart of various oral doses and their absorption.
This one is a discussion on which oral doses helped elderly patients the most:
http://www.ncbi.nlm.nih.gov/pubmed/15911731
Quote:
RESULTS:
Supplementation with cyanocobalamin in daily oral doses of 2.5, 100, 250, 500, and 1000 mug was associated with mean reductions in plasma methylmalonic acid concentrations of 16%, 16%, 23%, 33%, and 33%, respectively. Daily doses of 647 to 1032 mug of cyanocobalamin were associated with 80% to 90% of the estimated maximum reduction in the plasma methylmalonic acid concentration.
CONCLUSION:
The lowest dose of oral cyanocobalamin required to normalize mild vitamin B(12) deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 mug daily.
PMID:
15911731
[PubMed - indexed for MEDLINE]
|
And this review article from 2009:
Quote:
Int J Lab Hematol. 2009 Feb;31(1):1-8. Epub 2008 Nov 19.
Oral cobalamin (vitamin B(12)) treatment. An update.
Andrès E, Dali-Youcef N, Vogel T, Serraj K, Zimmer J.
Source
Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. andres@chru-strasbourg.fr
Abstract
The objective of this review was to evaluate oral cobalamin (vitamin B(12)) therapy in adult and elderly patients, from the perspective of a hematologist. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Data from our working group, the 'Groupe d'étude des carences en vitamine B(12)des Hôpitaux Universitaires de Strasbourg', have also been included. Several prospective studies in well-determined population (n = 4), prospective randomized studies (n = 3) and a systematic review by the Cochrane group (n = 1) provide evidence that oral cobalamin therapy may adequately treat cobalamin deficiency, particularly hematological abnormalities or manifestations. These studies suggest that at least 1000 microg/day of oral cyanocobalmin are needed for pernicious anemia and a mean daily dose of 250 microg for food-cobalamin malabsorption. This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients.
PMID:
19032377
[PubMed - indexed for MEDLINE]
|
You may copy these citations and give them to your doctor if he/she needs educating!
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