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Originally Posted by paula_w
Ann
As an advanced patient [balance and arthritis render me useless when off] , i agree with you completely. Perhaps [especially in cases of gene therapy and other brain surgeries] they know they will get better results with less advanced, thus allowing them to go forward and get approved.
IMHO that's a flaw - unfair and should be illegal. There are legitimate reasons to eliminate people from trials, but advanced patients obviously are more in need of relief and scientists who discriminate solely on what stage a person is in is hard to accept.
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I've also read that many researchers prefer newbies because they don't have to worry about drug interaction as much as with someone who is on the various PD med cocktails already. I get that, but also agree with Paula, that it's probably more because they know it's much more likely to look positive (and increase stock prices of the company making the drug) if it's only tested on newbies.