MrsD,

Thanks for your reply, I have seen reference to cryoglobulins but as you mentioned- mostly from sources outside of the U.S.

I recently visited my primary care DR regarding the little "mini cramps" that I have been experiencing in my legs at night; he put me on a 5 week regimen of Nortriptyline(10mg) which does gives me relief.

I hear that for many afflicted with PN the "electric" pain stabbing/prickling sensations are the main concern. For me it's mostly just a bizarre surface numbness, and some touch sensitivity; my feet/toes feel more normal when wearing some loose fitting cotton socks.

I had been hoping to put off treatment until the Hep C treatment by Pharmasset (without interferon) is approved and available, but with this PN worsening, and the possibility that it being linked to the Hep C, I may not be able to wait much longer.