Interfering with vagal nerve activity in mice prevents diabetes and hypertension.

"'Mice that can't make Ppara don't develop diabetes or hypertension in response to glucocorticoids," says Semenkovich, who also is chief of the Division of Endocrinology, Metabolism and Lipid Research. "The use of steroids is very common in medicine. People with asthma, arthritis, organ transplants and others rely on those steroid drugs, and many of them go on to develop insulin resistance that can advance to diabetes and hypertension.'

But in these most recent experiments, the researchers showed that both Ppara and the vagus nerve seem to play important roles in the development of these disorders."

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